Mastercam, like most high-end CAD/CAM software, is protected by a "dongle"—a physical USB key that must be plugged into the computer for the software to launch. Without the key, the software is a paperweight.
Reboot and reinsert dongle
If you are seeing a "driver corrupted or missing" message in the Device Manager, try these steps: mastercam x72022 virtual usb bus error link