The treatment of MDD, one of the most prevalent psychiatric disorders, has seen significant advancements. The monoamine hypothesis, which posits that depression is related to deficiencies in serotonin, norepinephrine, and dopamine, remains a cornerstone of antidepressant therapy. However, newer agents, such as vortioxetine and vilazodone, have expanded our understanding of the role of multiple neurotransmitter systems in MDD treatment.
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