We evaluate FPRE080 on a newly assembled benchmark (Dataset 015958) and compare its performance with leading tools. The results demonstrate that a carefully engineered minimal‑free‑energy approach can be both and accurate , thereby refuting the common belief that these goals are mutually exclusive.
FPRE080 significantly outperforms the baselines (paired t‑test, p < 0.001). The improvement is especially pronounced for long loops (>70 nt) where TPP‑38 reduces over‑penalization of large internal loops. fpre080 mina kitano015958 min free
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